scDiffCom infers cell type to cell type communication signals from scRNA-seq Seurat objects, and more particularly investigates how these interactions change between two biological conditions. The package relies on an internal collection of ligand-receptor interactions (available for human, mouse and rat) retrieved from seven public and curated databases.
Display LRI databases
# Install release version from CRAN install.packages("scDiffCom") # Install development version from GitHub devtools::install_github("CyrilLagger/scDiffCom")
For a concrete and large-scale project that used scDiffCom, please look at scagecom.org, our murine atlas of age-related changes in intercellular communication.
Please consider reading and citing our preprint here.