scDiffCom infers cell type to cell type communication signals from scRNA-seq Seurat objects, and more particularly investigates how these interactions change between two biological conditions. The package relies on a internal collection of ligand-receptor interactions (available for human and mouse) retrieved from seven public and curated databases.

Display LRI databases



# Install release version from CRAN

# Install development version from GitHub


As an introduction, please look at the documentation and this vignette.

For a concrete and large-scale project that used scDiffCom, please look at, our murine atlas of age-related changes in intercellular communication.


Please consider reading and citing our preprint here.